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TROPONIN I3
Descriptors Found:
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DeCS
Descriptor
English
:
Troponin I
Descriptor
Spanish
:
Troponina I
Descriptor
Portuguese
:
Troponina I
Synonyms
English
:
Troponin I1
Troponin I2
Troponin I3
Troponin-I
Tree Number:
D05.500.945.925
D05.750.078.730.825.925
D12.776.210.500.910.925
D12.776.220.525.825.925
Definition
English
:
A
TROPONIN
complex subunit that inhibits
ACTOMYOSIN
ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three
troponin I
subtypes:
troponin
I1, I2 and I3.
Troponin
I3 is cardiac-specific whereas
troponin
I1 and I2 are skeletal subtypes.
Troponin
I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and
mutations
in
troponin
I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Indexing Annotation
English
:
TROPONIN C
&
TROPONIN T
are also available
History Note
English
:
97; was TROPONIN I (NM) 1975-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33046
Unique Identifier:
D019210
Occurrence in VHL
:
Similar:
DeCS